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2 edition of role of PSD-95 in the regulation of Src within the NMDA receptor complex. found in the catalog.

role of PSD-95 in the regulation of Src within the NMDA receptor complex.

Lorraine Victoria Kalia

role of PSD-95 in the regulation of Src within the NMDA receptor complex.

by Lorraine Victoria Kalia

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  • 21 Currently reading

Published .
Written in English


Edition Notes

Thesis (Ph.D.) -- University of Toronto, 2004.

The Physical Object
Pagination272 leaves.
Number of Pages272
ID Numbers
Open LibraryOL20283178M
ISBN 100494026707

The period of early brain development involves an exceptional amount of neuronal morphological growth and refinement to form functional brain circuits. Although it is known that neural activity influences . Roger A. Johns, Yuan-Xiang Tao, Y.Z. Huang, L. Mei, Expression of PSD/SAP90 and its interaction with NMDA receptor and neuronal nitric oxide synthase in the spinal cord. 30th Annual Meeting .

Ferrante A, Martire A, Armida M, Chiodi V, Pezzola A, Potenza RL, Domenici MR, Popoli P () Influence of CGS , a selective adenosine A(2A) receptor agonist, on NMDA receptor function . Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface .

Targeting Kinase Interaction Networks: A New Paradigm in PPI Based Design of Kinase Inhibitors Author(s): Pranitha Jenardhanan, Centre for Bioinformatics, Pondicherry University, Puducherry, . NMDA receptor subunits were found to be up-regulated, but there was a down-regulation of several synaptic organizing proteins (PSD, Densin, septin6 homologue) and a synapse-enriched .


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Role of PSD-95 in the regulation of Src within the NMDA receptor complex by Lorraine Victoria Kalia Download PDF EPUB FB2

Regulation of Src within NMDA Receptor Complex. As in other systems, the activity of Src within the CNS is tightly regulated. At excitatory synapses in the adult CNS, the basal activity of Src is Cited by: In contrast, fewer NMDA receptor subunits on neural membranes are phosphorylated on tyrosine residues (2–4%).

Phosphorylation by Src enhances NMDA receptor function (Figure 8) by reducing. PSD (postsynaptic density protein 95) also known as SAP (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.

PSD is a member Aliases: DLG4, PSD95, SAP, SAP90, Dlgh4, PSD. Post-synaptic density protein 95 (PSD) links neuronal nitric oxide synthase (nNOS) with the N-methyl-D-aspartic acid (NMDA) receptor in the central nervous system, and this molecular complex. Protein kinase CK2 (CK2; formerly called casein kinase 2) is a ubiquitous serine-threonine kinase, that is highly concentrated in the brain, where it phosphorylates at least 78 different proteins, including Cited by: Thus, estrogen receptor-mediated stimulation of the nNOS/PSD/NMDA receptor complex assembly is likely to be a critical component of the signaling process by which estradiol facilitates coupling.

Ample evidence suggests a critical role for NMDARs in initiating MSN dysfunction and death in HD. The expression of mhtt may produce changes in NMDAR composition, trafficking, and function.

Chung HJ, Huang YH, Lau LF, Huganir RL () Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neuro. G Protein Coupled Receptors (GPCRs) are the largest family of receptors whose ligands constitute nearly a third of prescription drugs in the market.

They are widely involved in diverse physiological functions. Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein (SAP) is a protein that in humans is encoded by the DLG3 gene.

[5] [6] DLG3 is a member of the. The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone.

Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron – [The authors show that the activation of postsynaptic insulin.

Abstract. The Na + /K +-ATPase or sodium pump (NKA) is a membrane-anchored protein responsible for creating and maintaining the Na + and K + gradients across the plasma membrane of animal cells by.

NMDA receptors are a consistent feature of excitatory synapses of the forebrain, whereas AMPA receptor content is highly variable; indeed, a significant fraction of excitatory synapses lack AMPA receptors. Because the PSD/NMDA receptor complex is tightly associated with the PSD (Allison et al., ), this complex can provide rigid structural support for the recruitment of other PSD proteins.

It is therefore possible that the recruitment of pGAP to dendritic spines is mediated by a direct interaction with NMDA receptor complex. NMDA receptor activation in hippocampal CA1 pyramidal cell Release of Ca+2 Activation of kinases/ phosphatases CaMKII +NMDA receptor complex Hyperphosphorylation Integration of.

NMDA and AMPA receptors interact with the postsynaptic density (PSD) protein, a scaffolding protein that recruits receptors and signaling molecules. The interaction of glutamate receptors with PSD has neuroprotective implications for HD.

PSD contains the domain Src. Thus, this receptor can also play a major role in the rapid neuronal adaptation to changes of the redox potential in the extracellular fluids within the brain, and the different types of NMDA-receptors display.

Book Section Chapter Conference Paper Conference Poster Document Review Thesis Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD complex.

NATURE COMMUNICATIONS. Academic Article. The NMDA receptor complex. P Claude COLOMER, Rotterdam - Action potential regulation of Arc expression P Sarah COUSINS, London - NETO-1 associates with the NMDA receptor/APP protein complex P Patrizia.

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. ;– Crossref, Medline, Google Scholar; Jouvenceau A. Furthermore, Numb formed a complex with EphB2 receptor-type tyrosine kinase and NMDA-type glutamate receptors.

Knockdown of Numb suppressed the ephrin-B1-induced spine development and maturation. These results highlight a role .PSD and SAP are examples ofglutamate receptor scaffolding proteins, which have beenimplicated in the trafficking and anchoring of glutamate re-ceptor subunits.

In the present study, we did not detect anychanges in PSD